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PCP, or phencyclidine, is well-documented for inducing combative behavior and disorientation among users. This dissociative anesthetic affects the central nervous system and alters perception of reality, often leading to agitation and aggressive actions. Users may experience hallucinations and changes in sensory perception, contributing to a state of confusion and disorientation. The effects of PCP can also lead to erratic and unpredictable behaviors, which can include violence or combative actions.

In contrast, other substances listed have different behavioral effects. Cannabis is more commonly associated with relaxation and altered mood, while ketamine, though it has dissociative properties, tends to induce a sense of detachment rather than aggression. LSD primarily leads to altered sensory perceptions and intense visual experiences, often described as euphoric rather than combative. Thus, PCP is the substance most closely aligned with causing the described symptoms.